Hepatitis A in Mexico: Your Essential Guide to Twinrix for Travelers & Expats

Medically reviewed by Vadzim B. - PharmD on Jul 7 2025

Mexico, with its vibrant culture, stunning landscapes, and delicious cuisine, is a top destination for travelers and a popular choice for expats seeking a new home. However, like any international destination, it comes with its own set of health considerations. One significant concern for visitors and residents alike is Hepatitis A. Understanding the risks and preventative measures, particularly regarding the Twinrix vaccine, is crucial for a safe and healthy experience in Mexico.

Understanding Hepatitis A: Risks in Mexico

Hepatitis A in Mexico is a concern due to its prevalence in regions where sanitation and hygiene standards may vary. It's a viral liver infection that can range from mild to severe, and while it's rarely fatal, it can cause debilitating symptoms and lead to significant disruption to your travel plans or daily life as an expat. The virus is primarily transmitted through the fecal-oral route, meaning it spreads when an uninfected person ingests food or water contaminated with the feces of an infected person [1]. This can happen through:

• Contaminated food and water: This is the most common route of transmission for travelers. Unwashed produce, uncooked shellfish, and contaminated ice are common culprits.
• Close personal contact: Direct contact with an infected person, even if they don't show symptoms, can transmit the virus.

Even if you're staying in high-end resorts or popular tourist areas, the Hepatitis A Mexico risk remains. The virus can be present in food prepared by infected individuals or in water used for washing produce, regardless of the establishment's perceived cleanliness. Therefore, taking proactive steps to protect yourself is paramount.

Do I Need Twinrix for Mexico? The Importance of Vaccination

For anyone planning to travel to or reside in Mexico, the answer to the question, "Do I need Twinrix for Mexico?" is a resounding yes. The Centers for Disease Control and Prevention (CDC) and other health organizations strongly recommend Hepatitis A vaccination for most travelers to Mexico [2].

Twinrix is a combined vaccine that provides protection against both Hepatitis A and Hepatitis B. This dual protection is highly beneficial, as Hepatitis B is also a global health concern, though its transmission differs (primarily through blood and bodily fluids). For travelers and expats, the convenience of a single vaccine protecting against two significant health risks is a major advantage.

Book a consultation with English-speaking travel health specialists to discuss your vaccination needs for Mexico.

Twinrix: Schedule, Booster, and Duration of Protection

Understanding the Twinrix schedule is important for ensuring optimal protection. The standard vaccination course typically involves three doses:

• First dose: Administered on day 0.
• Second dose: Administered one month after the first dose.
• Third dose: Administered six months after the first dose.

There is also an accelerated schedule available for adults who need faster protection, which involves four doses over a shorter period (e.g., 0, 7, 21-30 days, and a booster at 12 months) [3]. It's crucial to complete the full series for long-term immunity.

Regarding the Twinrix booster, once the primary series is completed, long-term protection is generally achieved. Studies suggest that the protection from Twinrix can last for at least 20 years, and potentially for life, for Hepatitis A [4]. For Hepatitis B, protection is also long-lasting, and routine boosters are generally not recommended for immunocompetent individuals after completing the primary series [5]. This addresses the common question, "How long is Twinrix good for?" – offering peace of mind for extended stays or frequent travel.

Twinrix Cost and Accessibility

The Twinrix cost can vary depending on your location, insurance coverage, and the clinic administering the vaccine. It's advisable to check with your healthcare provider or travel clinic for specific pricing information. While there is an upfront cost, consider it an investment in your health and peace of mind, especially given the potential medical expenses and disruption that a Hepatitis A infection could cause.

Beyond Vaccination: General Hepatitis Information

While vaccination is your best defense against Hepatitis A, it's also helpful to understand some general facts about hepatitis:

• Causes of hepatitis: Hepatitis refers to inflammation of the liver. It can be caused by viruses (like Hepatitis A, B, C, D, and E), alcohol abuse, certain medications, autoimmune diseases, and other factors.
• Is hepatitis contagious: Yes, many forms of hepatitis are contagious, but the modes of transmission vary. Hepatitis A and E are typically spread through contaminated food and water, while Hepatitis B, C, and D are primarily spread through blood and bodily fluids.
• Hepatitis treatment: Treatment for hepatitis depends on the type and severity. Acute Hepatitis A usually resolves on its own with supportive care. Chronic forms of hepatitis (like B and C) may require antiviral medications.
• Is hepatitis curable: Hepatitis A is generally not curable in the sense that there's no specific antiviral drug, but the body usually clears the infection on its own. Hepatitis C is curable with modern antiviral treatments. Hepatitis B is often manageable but not always curable.